Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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3,766 – 3,780 of 5,528 results

3,766

Apexbio Technology LLC Emodin 518-82-1 200mg

Emodin (518-82-1) is a small-molecule inhibitor targeting casein kinase 2 (CK2) and the interaction between SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) It is designed to block protein protein interactions and enzyme activity thereby modulating viral entry and kinase-mediated signaling Emodin exerts its biological activity primarily through inhibition of CK2 and disruption of spike ACE2 binding In hepatocellular carcinoma cell models (Hep3B HepG2 Huh7) emodin demonstrates antiproliferative activity with IC50 values of 66 9 M in Hep3B 74 36 M in HepG2 and 101 5 M in Huh7 cells Based on these pharmacological properties emodin holds research potential in cancer inflammation metabolic disorders and viral infection models

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3,767

Medchemexpress LLC Revumenib | 2169919-21-3 | 99.99% | 630.82 | 200 MG

Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell-based IC50 of 10-20 nM. It is intended for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). For research use only; not for sale to patients.

Potent and specific Menin-MLL inhibitor.
Applicable for research in MLL-rearranged acute leukemias (ALL and AML).
Shows in vivo plasma IC50 of 53 nM.
Provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts in vivo.

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3,768

Medchemexpress LLC BML-284 | 853220-52-7 | 100.0% | 350.37 | 200 MG

BML-284 is a potent and cell-permeable Wnt signaling activator. It induces TCF-dependent transcriptional activity with an EC50 of 700 nM.

Potent Wnt signaling activator
Cell-permeable
Induces TCF-dependent transcriptional activity

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3,769

Medchemexpress LLC Apilimod | 541550-19-0 | 99.8% | 418.49 | 200 MG

Apilimod is a potent IL-12/IL-23 inhibitor, strongly inhibiting IL-12 with IC50s of 1 nM and 2 nM in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively. It is also described as a potent and highly selective PIKfyve inhibitor.

Potent IL-12/IL-23 inhibitor
Strongly inhibits IL-12 with IC50s of 1 nM and 2 nM
Potent and highly selective PIKfyve inhibitor
Inhibits IFN-γ production in human PBMCs
Reduces severity of experimental autoimmune uveoretinitis (EAU)
Lowers level of IL-12 p40 in serum without altering body weight in EAU mice
Effective in Th1 model, with 51%±8% inhibition

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3,770

Medchemexpress LLC Zorifertinib | 1626387-80-1 | 99.4% | 459.90 | 200MG

Zorifertinib (AZD3759) is a potent, orally active, and BBB-penetrant EGFR inhibitor. Its IC50s are 0.3, 0.2, and 0.2 nM for EGFR wt, EGFR L858R, and EGFR exon 19Del, respectively, at Km ATP concentrations. This compound induces cancer cell apoptosis and exhibits antitumor activity, making it suitable for research in NSCLC, HCC, and similar conditions.

Potent EGFR inhibitor
Orally active
BBB-penetrant
Induces cancer cell apoptosis
Exhibits antitumor activity
Applicable for NSCLC, HCC, and other research areas

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3,771

Medchemexpress LLC Tigecycline | 220620-09-7 | 99.95% | 200 MG

Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic. It has been shown to inhibit AML2 and HL-60 cells, with specific IC50 values. Its activity extends to bacterial strains, demonstrating a mean inhibitory concentration (MIC) of approximately 125 ng/mL for E. coli (MG1655 strain), and MIC50 and MIC90 values of 1 and 2 mg/L, respectively, for Acinetobacter baumannii.

Broad-spectrum glycylcycline antibiotic
Inhibits AML2 and HL-60 cells in vitro
Demonstrates activity against E. coli and Acinetobacter baumannii
Light yellow to orange solid appearance
Derived from microorganisms
Reduced tumor volume and weight in an AML xenograft model

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3,772

Apexbio Technology LLC GSK1838705A 1116235-97-2 200mg

GSK1838705A (CAS 1116235-97-2) is a small molecule inhibitor targeting the kinase activity of insulin-like growth factor-1 receptor (IGF-1R) insulin receptor and anaplastic lymphoma kinase (ALK) It exhibits potent inhibition with IC50 values of 2 0 nM for IGF-1R 1 6 nM for insulin receptor and 0 5 nM for ALK In preclinical research GSK1838705A suppresses proliferation of hematologic malignancy-derived tumor cells including multiple myeloma and Ewing sarcoma lines and inhibits tumor xenograft growth in vivo Additionally despite targeting the insulin receptor it minimally affects glucose homeostasis at effective doses Due to its multi-target kinase inhibitory profile GSK1838705A serves as a promising tool for cancer biology research

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3,773

eMolecules 7681-84-7 | Tetrahydro-furan-2-carbaldehyde, 50%w/w in toluene | J&W PharmLab LLC | MFCD01726184 | 100.117 | C5H8O2 | 95.000 | O=CC1CCCO1 | 100mg | 592889055

Tetrahydro-furan-2-carbaldehyde, 50%w/w in toluene | J&W PharmLab LLC | 7681-84-7 | MFCD01726184 | 100.117 | C5H8O2 | 95.000 | O=CC1CCCO1 | 100mg | 592889055

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3,774

Medchemexpress LLC Ethyl indole-2-carboxylate | 3770-50-1 | 99.7% | 189.21 | 50 G

2-Carbethoxyindole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.
An indole derivative.
Inhibits benzodiazepine receptor with IC50= 2.2 mM.

Pricing & Availability

3,775

Medchemexpress LLC BPTES | 314045-39-1 | 98.0% | 200 MG

BPTES is an allosteric and selective glutaminase inhibitor with an IC50 of 0.16 μM. It is for research use only.

Inhibits glutaminase activity
Diminishes glutamate and α-KG levels
Increases glycolytic intermediates
Inhibits PDAC cell proliferation
Slows growth of mutant IDH1 cells
Shows synergistic anti-cancer effect with 5-FU in A549 and EKVX cell lines
Reduces growth in most NSCLC cell lines
Reduces levels of TCA cycle metabolites
Reduces ATP production
Attenuates tumor growth in patient-derived pancreatic orthotopic tumor models

Pricing & Availability

3,776

eMolecules 345909-35-5 | 4-Hydroxyquinoline-2-carboxylic acid hydrate | Apollo Scientific | MFCD00149476 | 207.185 | C10H9NO4 | 95.000 | O.OC(=O)c1cc(O)c2ccccc2n1 | 1g | 562444254

4-Hydroxyquinoline-2-carboxylic acid hydrate | Apollo Scientific | 345909-35-5 | MFCD00149476 | 207.185 | C10H9NO4 | 95.000 | O.OC(=O)c1cc(O)c2ccccc2n1 | 1g | 562444254

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3,777

Apexbio Technology LLC Trospium chloride 10405-02-4 200mg

Trospium chloride (CAS 10405-02-4) is a quaternary ammonium compound that functions as a competitive antagonist at muscarinic acetylcholine receptors thereby inhibiting cholinergic stimulation of the bladder detrusor muscle This action reduces involuntary bladder contractions leading to decreased urinary urgency frequency and urge incontinence Trospium chloride displays pharmacological properties distinct from tertiary amine antimuscarinics including limited central nervous system penetration It is widely utilized in preclinical and clinical research focused on urinary disorders and muscarinic receptor pharmacology

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3,778

Medchemexpress LLC Tavaborole | 174671-46-6 | 99.7% | 151.93 | 1 ML

Tavaborole is an antifungal agent primarily active against Trichophyton species, developed as a topical solution for the treatment of onychomycosis. It is intended strictly for research purposes and not sold to patients.

Antifungal agent with activity against Trichophyton species.
Used in a topical solution formulation for the potential treatment of onychomycosis.
Demonstrates an 8-fold increase in activity against C. neoformans and A. fumigatus in vitro.
Inhibits cells expressing GlLeuRS-D444A.

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3,779

Madecassoside | 34540-22-2 | 975.12 | 200 MG" aria-hidden="true" src="https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg" data-testid="ResultImage" >

Medchemexpress LLC Madecassoside | 34540-22-2 | 975.12 | 200 MG

Madecassoside is a pentacyclic triterpene isolated from Centella asiatica with anti-inflammatory, antioxidant, and anti-aging properties. It is orally active and inhibits inflammation, oxidation, apoptosis, and autophagy by inhibiting p38 MAPK and NF-κB activities, exhibiting anti-apoptotic properties, and activating Nrf2 expression. It has potential applications in endocrine, cardiovascular, and skin diseases.

Isolated from Centella asiatica.

Anti-inflammatory, antioxidant, and anti-aging effects.

Orally active.

Inhibits inflammation, oxidation, apoptosis, and autophagy.

Inhibits p38 MAPK and NF-κB activities.

Exhibits anti-apoptotic properties.

Activates Nrf2 expression to reduce neurotoxicity.

Potential for endocrine, cardiovascular, and skin diseases.

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3,780

Medchemexpress LLC NP118809 | 41332-24-5 | 98.73% | C₃₂H₃₂N₂O | 200 MG

NP118809 is a potent N-type calcium channel blocker with an IC₅₀ of 0.11 μM, and also inhibits L-type calcium channels less potently with an IC₅₀ of 12.2 μM. It is intended for research use only.

Potent N-type calcium channel blocker (IC₅₀ of 0.11 μM).
Inhibits L-type calcium channels (IC₅₀ of 12.2 μM).
Shows significant analgesic activity in the phase IIA portions of the rat formalin model (25 mg/kg, i.p.).
Results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model (30 mg/kg, p.o.).
Available in solid form, light yellow to yellow in color.

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Quinolines and derivatives

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Medchemexpress LLC Revumenib | 2169919-21-3 | 99.99% | 630.82 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC BML-284 | 853220-52-7 | 100.0% | 350.37 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Apilimod | 541550-19-0 | 99.8% | 418.49 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Zorifertinib | 1626387-80-1 | 99.4% | 459.90 | 200MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Tigecycline | 220620-09-7 | 99.95% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ethyl indole-2-carboxylate | 3770-50-1 | 99.7% | 189.21 | 50 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC BPTES | 314045-39-1 | 98.0% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Tavaborole | 174671-46-6 | 99.7% | 151.93 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Madecassoside | 34540-22-2 | 975.12 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC NP118809 | 41332-24-5 | 98.73% | C₃₂H₃₂N₂O | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More